Serum Trace Elements and Oxidative Stress Marker in Children with Febrile Seizure

Febrile seizures are the most common seizures in the childhood. The exact aetiopathogenesis of febrile seizures is unknown. Objectives: The present study was conducted to evaluate the serum Zinc (Zn), Copper (Cu), Magnesium (Mg) and plasma Malondialdehyde (MDA) levels in patients with febrile seizures (FS). Methods: The study subjects included 20 cases of children with FS, 20 children with only fever and 20 healthy children as controls. Children of 6months – 5 yrs were included in the study group. The Zn, Cu, MDA levels were analyzed by spectrophotometer and Mg by auto analyzer. Results: The mean serum Zn and Mg values were significantly decreased in FS in comparison to children with only fever and control group (P < 0.05). The mean serum Cu and plasma MDA levels were increased in FS children when compared with other two groups (P < 0.05). Conclusion: The findings of the present study suggest that high serum Cu and plasma MDA; reduced serum Zn and Mg may be responsible for enhanced neuronal excitability in children with febrile seizures.

Author(s): Dr. Iyshwarya U , Dr P.S. Pawan Kalyan , Dr Suma H.R , Dr Prabhavati , Dr Aruna Kumari R

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