Hypertension is a part of metabolic syndrome affecting millions of people across the globe. Though early detection and timely meditation decreases the chances of Coronary- Vascular- Disease(CVD) and angiopathies which increases the life expectancy, but the Resistant Hypertension is increasing which reduces the overall morbidity and mortality. Hence detecting newer targets and to supplement main-line therapy is essential to control the ever-increasing Hypertension. Â